Characterization and classification of matrix effects in biological samples analyses.
نویسندگان
چکیده
An exhaustive classification of matrix effects occurring when a sample preparation is performed prior to liquid-chromatography coupled to mass spectrometry (LC-MS) analyses was proposed. A total of eight different situations were identified allowing the recognition of the matrix effect typology via the calculation of four recovery values. A set of 198 compounds was used to evaluate matrix effects after solid phase extraction (SPE) from plasma or urine samples prior to LC-ESI-MS analysis. Matrix effect identification was achieved for all compounds and classified through an organization chart. Only 17% of the tested compounds did not present significant matrix effects.
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عنوان ژورنال:
- Journal of chromatography. A
دوره 1217 25 شماره
صفحات -
تاریخ انتشار 2010